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GB 115 10ML NASAL SPRAY 2MG/ML

GB 115 10ML NASAL SPRAY 2MG/ML

Original price was: $99.00.Current price is: $89.00.

ANCIETY SUPPORT (GAD)

11 in stock

SKU: PROD 26 Categories: ,
GB-115 (CAS 678996-63-9) is an experimental anxiolytic drug and peptide antagonist of central cholecystokinin-1 (\(CCK_{1}\)) receptors under investigation for treating generalized anxiety disorder (GAD), neurasthenia, and adjustment disorders. Developed in Russia, it shows promise in reducing anxiety with mild psychostimulant properties and cognitive benefits, having completed Phase 3 trials. 
Key Aspects of GB-115
    • Clinical Efficacy: In trials, a 6 mg daily dose of GB-115 (also known as Ranquilon) proved effective for GAD, significantly lowering MFI-20 anxiety scores by day 3, with effects continuing up to 21 days.
    • Mechanism of Action: As a retrodipeptide analogue of cholecystokinin-4, it acts as a central \(CCK_{1}\) receptor blocker and has shown potential \(CCK_{2}\) receptor antagonism in animal models.
  • Key Benefits: Research indicates it reduces emotional stress, increases reaction speed, improves attention, and is different from traditional SSRIs/SNRIs.
  • Safety Profile: Studies noted no significant stimulation-related side effects, unlike some stimulants, and it has shown anxiolytic effects comparable to phenazepam.
  • Current Status: DrugBank records indicate it has completed Phase 3 trials in Russia for neurasthenia, adjustment disorders, and anxiety.

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